The image shows diabetic kidney disease Comment Here Reference: Diabetic kidney disease. Board review style question 2. On immunofluorescent microscopy what is the usual finding in diabetic kidney disease? Diffuse mesangial staining for IgA Diffuse coarse granular staining of C3 along the glomerular capillaries and mesangium Diffuse coarse granular staining of IgG along the glomerular capillaries Dull linear staining of glomerular and tubular basement membranes for IgG Immunofluorescent microscopy is typically negative.
Board review style answer 2. Dull linear staining of glomerular and tubular basement membranes for IgG Comment Here Reference: Diabetic kidney disease. Board review style question 3. In a patient suspected to have diabetic kidney disease, what is the earliest structural change in a kidney biopsy recognized by electron microscopy? Deposits of randomly oriented nonbranching fibrils in the mesangium Diffuse thickening of the glomerular basement membrane Diffuse effacement of podocytes' foot processes Electron dense subepithelial deposits Expansion of the mesangial regions.
Board review style answer 3. Diffuse thickening of the glomerular basement membrane Comment Here Reference: Diabetic kidney disease. Sign up for our Email Newsletters. Click here for information on linking to our website or using our content or images. Home About Us Advertise Amazon. Telephone: ; Email: CommentsPathout gmail. This website is intended for pathologists and laboratory personnel but not for patients.
We welcome suggestions or questions about using the website. However, we cannot answer medical or research questions or give advice. Both FMs and KW nodules consisted of a spectrum of lesions. For the sake of clarity they were arbitrarily divided into two types: edematous and proliferative FMs and simple and complicated KW nodules.
Complicated nodules were associated with marked alterations in the lobular capillary. While diabetic nephropathy is an extremely common etiology of kidney disease, it is important to recognize that other forms of nodular glomerulosclerosis also exist. For example, idiopathic nodular glomerulosclerosis may be present in patients without diabetes, often in older men with a combination of hypertension and longstanding tobacco use.
These nodules like Kimmelstiel-Wilson lesions are collagenous proliferations that appear to push the mesangial cells to the edge of the nodule, and stain very positive with both the PAS and the Jones silver stain.
In contrast, nodules can also be seen in deposition diseases such as amyloidosis. These nodules are, in part, composed of the amyloid protein configured in beta-pleated sheets that do not stain strongly on PAS and that are negative on the Jones silver stain. Immunofluoresence will typically confirm diabetic nephropathy via a weak linear basement membrane IgG staining, whereas MIDD or light chain amyloidosis will be restricted to the abnormal light chain clone.
0コメント